Cancer Genetics
Study doesn't support different offspring sex ratios between BRCA1/2 carriers
Published in Women's Health Weekly, October 14th, 2004
According to J.P. Struewing and colleagues, "Two recent papers suggest distorted sex and transmission ratios associated with BRCA1 mutations. If real, these would provide novel insights into the normal biological function of this gene and have implications for genetic epidemiologic methods used to estimate penetrance.
"We addressed these observations in two settings: offspring of 283 mutation carriers and 471 mutation negative subjects from BRCA1/2 mutation-positive families with...
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