Cervical Cancer

Activation of Notch in cervical neoplasia appears to be Jagged1 dependent

Published in Women's Health Weekly, October 14th, 2004

According to a study from India, "Infection by high-risk human papillomaviruses (HPV) and persistent expression of viral oncogenes E6 and E7 are causally linked to the development of cervical cancer. These oncogenes are necessary but insufficient for complete transformation of human epithelial cells in vivo.

"Intracellular Notch1, protein is detected in invasive cervical carcinomas (ICC), and truncated Notch1 alleles complement the function of E6/E7 in the transformation of human epithelial cells," wrote K. Veeraraghavalu and colleagues, University of Agriculture Science, Bangalore.

This team "[investigated] potential mechanisms of Notch activation...

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Source: Women's Health Weekly (2004-10-14)

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