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Cervical Cancer

C-kit protein overexpression occurs infrequently in small cell carcinomas

Published in Women's Health Weekly, October 14th, 2004

Overexpression of c-kit protein occurs infrequently in small cell carcinoma of the uterine cervix, which may indicate different etiopathogenic mechanisms for this type of small cell carcinoma than those leading to other types.

According to a study from the United States, "Primary small cell carcinomas of the uterine cervix are uncommon but highly aggressive malignancies. The recent observations that c-kit proto-oncogene, a tyrosine kinase, is overexpressed in small cell lung cancers and that advanced c-kit-expressing gastrointestinal stromal tumors were successfully treated with a selective tyrosine kinase inhibitor STI-571 (Gleevec, imatinib mesylate) prompted us to...

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