Drug Development
ErbB-2 kinase inhibitor has potential as anti-cancer drug
Published in Women's Health Weekly, October 14th, 2004
According to researchers in China, "Human cancers frequently express high levels of ErbB-2 tyrosine kinase, which is associated with aggressive tumor behavior and poor prognosis. ErbB-2 is thus a promising target for cancer therapy."
In their study, X.N. Guo and colleagues at the Chinese Academy of Science in Shanghai expressed "the catalytic domain of ErbB-2 as a soluble active kinase, and [investigated] the correlations between its activity and kinase concentration, ATP concentration, substrate...
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