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Stem Cell Research

Model transforms stem cells to express breast cancer estrogen receptor

Published in Women's Health Weekly, October 21st, 2004

A model is proposed to transform stem cells to express the breast cancer estrogen receptor.

"Recently, substantial progress has been made in the identification and characterization of stem and progenitor cells in the mouse and human mammary gland. Furthermore, there is accumulating evidence that these cells might be targets for transformation during mammary carcinogenesis," scientists in the United States said.

"On the basis of this stem cell concept," report G. Dontu and colleagues, "we propose a model in which the transformation of different subsets of stem and progenitor cells results in the diversity of breast cancer phenotypes, including...

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