Colon & Breast Cancer
New assay can measure capecitabine and its metabolites in plasma
Published in Women's Health Weekly, October 21st, 2004
"Capecitabine (N-4-pentoxycarbonyl-5'-deoxy-5-fluorocytidine, Xeloda), a prodrug of 5-fluorouracil (5-FU), is an oral tumor-selective fluoropyrimidine carbamate approved in the treatment of colorectal and breast cancer. It has a preferential activation to 5-FU by thymidine phosphorilase (TP) in target tumor tissues through a series of three metabolic steps minimizing the exposure of normal tissues to 5-FU," scientists in Spain report.
"It offers the potential of less gastrointestinal toxicity...
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