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Endocrinology

Estrogen-responsive genes identified in novel pituitary cell line

Published in Women's Health Weekly, October 21st, 2004

A number of estrogen-responsive genes have been identified in a novel pituitary cell line.

"To identify estrogen-responsive genes in somatolactotrophic cells of the pituitary gland, a rat pituitary cell line GH3 was subjected to cDNA microarray analysis" in a recent study from Japan.

"GH3 cells respond to estrogen by growth as well as prolactin synthesis," N. Fujimoto and coauthors at Hiroshima University found. "RNAs extracted from GH3 cells treated with 17beta-estradiol (E2) at 10-9 M for 24 h were compared with the control samples."

"The effect of an anti-estrogen IC1182780 was also examined," the scientists noted....

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