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Hormone Replacement Therapy

HRT linked to IgM anticardiolipin antibody increase in postmenopausal women

Published in Women's Health Weekly, November 4th, 2004

Hormone replacement therapy is associated with increased levels of immunoglobulin M anticardiolipin antibodies in healthy postmenopausal women, researchers report.

M. Todorova of the Medical University of Sofia, Bulgaria, and colleagues studied the effects of hormone replacement therapy (HRT) on immunoglobulin (Ig) G and IgM anticardiolipin (aCL) antibodies.

They divided "30 clinically healthy postmenopausal women with no history of previous thrombotic events or autoimmune disease . . . in two groups: control group (n=12, mean age 52.9 ± 4.5 years, and 6.2 ± 3.6 years duration of amenorrhea) and a second group (n=18, mean age 53.6...

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