Liver Cancer
Estrogen plays a critical role in female hepatocarcinogenesis
Published in Women's Health Weekly, November 4th, 2004
According to researchers in Japan, "Estrogen has been related to the development of hepatocellular carcinoma (HCC).
"In this molecular epidemiological study, we used logistic regression to compare the genotype frequencies of estrogen-metabolizing genes that are involved in estrogen biogenesis (CYP17), hydroxylation (CYP1A1) and inactivation of the reactive metabolites (catechol-O-methyltransferase, COMT) in HCC patients and control subjects, and determined their relationship with the risk of female HCC."
"The heterozygous or homozygous variants of high activity CYP17...
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