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Gynecologic Cancers

Lymphocyte activation occurs early in invasive endometrial, cervical cancer

Published in Women's Health Weekly, November 4th, 2004

According to a study from Greece, "Major histocompatibility complex (HLA system) class II molecules including HLA-DR antigens, associate with peptides, which are derived from antigens, for presentation to T4 lymphocytes.

"Functional and adhesion assays have shown that CD4 molecule interacts with HLA class II molecules, leading to enhanced responses of T4 cells.

"In the present study, we examined the tissue expression of HLA-DR antigens and the quantitative variance of T4 lymphocytes in a series of 50 'endometrioid' adenocarcinomas of the endometrium and 35 cervical squamous-cell carcinomas," said A.C. Lazaris, University of Athens, and...

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