Immunology
Folate deficiency inhibits CD8+ cell proliferation
Published in Women's Health Weekly, November 11th, 2004
According to recent research published in the Journal of Immunology, "Folate is required for one-carbon transfer reactions and the formation of purines and pyrimidines for DNA and RNA synthesis. Deficiency of folate can lead to many clinical abnormalities, including macrocytic anemia, cardiovascular diseases, birth defects, and carcinogenesis. The nucleotide imbalance due to folate deficiency causes cell cycle arrest in the S phase and uracil misincorporation into DNA, which may result in DNA double-strand breaks during repair."
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