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Prognostics

New protein associated with aggressiveness in breast and ovarian cancer

Published in Women's Health Weekly, November 18th, 2004

A team led by University of Texas M.D. Anderson Cancer Center researchers has found a potential new protein marker for prognosis of breast and ovarian cancer.

In the November 2004 issue of the journal Nature Medicine, the researchers report tumor cells that "overexpress" the protein Rab25 are more aggressive and associated with poorer outcome. Thus, Rab25 could represent a novel therapeutic target or marker of tumor behavior, they say.

The scientists matched tumor samples to outcomes in about 100 patients diagnosed with either breast or ovarian cancer and found that a low level of Rab25 protein on a patient's cancer sample was associated with...

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