Systemic Lupus Erythematosus
Natural antibodies can promote ischemia/reperfusion injury seen in SLE
Published in Women's Health Weekly, December 2nd, 2004
"Natural antibodies have been implicated in initiating mesenteric ischemia/reperfusion (I/R)-induced tissue injury. Autoantibodies have affinity and self-antigen recognition patterns similar to natural antibodies. We considered that autoimmunity-prone mice that express high titers of autoantibodies should have enhanced I/R-induced injury," said Walter Reed Army Research Institute, USA, researchers.
"Five-month-old B6.MRL/lpr mice displayed accelerated and enhanced intestinal I/R-induced damage compared...
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