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Hormone Therapy

Oxidative metabolism of estrogen modulates ERT/HRT response in older women

Published in Women's Health Weekly, December 9th, 2004

The oxidative metabolism of estrogen modulates postmenopausal women's response to hormone therapy, researchers report.

In earlier work, R.C. Armamento-Villareal at Barnes Jewish Hospital in St. Louis, Missouri, and colleagues showed "that estrogen metabolism is one of the determinants of bone density after menopause. Increased hydroxylation to relatively nonestrogenic metabolites 2-hydroxyestrone (2OHE(1)) and 2-methoxyestrone (2MeOE(1)) was associated with low bone mineral density (BMD), while increased hydroxylation to the potent 16u-hydroxyestrone (16alphaOHE(1)) and weakly estrogenic estriol (E-3) was associated with higher BMD."

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