Oncology
Estrogen receptor beta makes breast cancer cells susceptible to retinoic acid
Published in Women's Health Weekly, December 16th, 2004
"The ability of retinoids to inhibit breast cancer cell growth correlates with estrogen receptor (ER) alpha status, as shown by the anti-proliferative effects of retinoids in ERalpha-positive breast cancer cells and their use as chemopreventive agents in premenopausal women. The discovery of ERbeta, also present in breast cancer cells, has added a new level of complexity to this malignancy," scientists in Canada report.
"To determine the retinoid response in ERbeta-expressing breast cancer cells, we used retroviral transduction of ERbeta in ER-negative MDA-MB-231 cells,"...
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