Women's Health Weekly
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Cervical Cancer
FRA8C is involved in HPV integration and chromosomal translocations
December 16th, 2004
According to a study from the Netherlands, "Molecular cytogenetic analysis frequently shows human papillomavirus (HPV) integration near translocation breakpoints in cervical cancer cells. "We have recently described a cluster of HPV 18 integrations in the distal end of the common fragile site FRA8C at 8q24 in primary cervical carcinoma samples. Chromosome band 8q24 contains the MYC gene (alias c-MYC), FRA8C, and FRA8D. The MYC gene is frequently deregulated - usually by translocation or amplification - in various tumor types," said M.J. Ferber, Vrije University of Amsterdam, and colleagues. In their current study, published in Cancer Genetics and...
Source: Women's Health Weekly (2004-12-16)
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