Women's Health Weekly
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Chlamydia
Chlamydia inhibit host-cell apoptosis by degrading proapoptotic proteins
December 16th, 2004
Chlamydia trachomatis and C. pneumoniae both inhibit host-cell apoptosis by degrading proapoptotic BH3-only proteins, microbiologists demonstrated. "Chlamydia are obligate intracellular bacteria that replicate in a vacuole inside a host cell. Chlamydial infection has been shown to protect the host cell against apoptotic stimuli. This is likely important for the ability of Chlamydia to reproduce in human cells," wrote S.E. Fischer and colleagues, Technical University of Munich. In their current study, Fischer's group were able to "show that resistance to apoptosis is conveyed by the destruction of the proapoptotic BH3-only...
Source: Women's Health Weekly (2004-12-16)
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