Women's Health Weekly
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Contraceptive Vaccine
Fusing molecular adjuvant to hCG protein antigen enhances humoral immunity
December 16th, 2004
Fusing molecular adjuvant C3d3 to the human chorionic gonadotropin (hCG) beta protein antigen enhanced humoral immunity. "The vaccine directed against human chorionic gonadotropin (hCG) has previously undergone clinical test demonstrating the feasibility of the approach in preventing pregnancy in women. Some individuals, however, did not response adequately despite employing highly immunogenic bacterial toxoids as carriers. In this study, we investigated the potential of three copies of Cad as a new molecular adjuvant to enhance the immunogenicity of hCG-beta protein antigen. The antibody response to the hCG-beta-C3d3 fusion protein immunization was compared with those...
Source: Women's Health Weekly (2004-12-16)
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