Women's Health Weekly
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Environmental Health
Effects of amitraz on P450 and estrogen activity determined
December 16th, 2004
The effects of amitraz exposure on P450 and estrogen activity have been characterized in vitro and in vivo. In a recent study, toxicologists in Taiwan "investigated the ability of amitraz, a formamidine insecticide, to induce cytochrome P450-dependent monooxygenases and to disrupt estrogenic activity in human breast cancer MCF-7 cells and immature female rats." "In MCF-7 cells, treatment with 10 microM amitraz for 24 h increased 7-ethoxyresorufin O-deethylase activity in cell homogenate," T.H. Ueng and coauthors at the National Taiwan University found. "Treatment of MCF-7 cells with 1 and 10 microM amitraz for 3 h replaced previously bound...
Source: Women's Health Weekly (2004-12-16)
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