Women's Health Weekly
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Enzymology
Polymorphism in a key folate enzyme influences DNA methylation in young women
December 16th, 2004
Polymorphism in a key folate enzyme influences DNA methylation in young women. "DNA methylation is critical for normal genomic structure and function and is dependent on adequate folate status. A polymorphism (677C-->T) in a key folate enzyme, methylenetetrahydrofolate reductase (MTHFR), may impair DNA methylation when folate intake is inadequate and may increase the risk of reproductive abnormalities," scientists in the United States say. "The present study was designed to evaluate the effect of the MTHFR 677C-->T polymorphism on changes in global DNA methylation in young women consuming a low folate diet followed by repletion with the current...
Source: Women's Health Weekly (2004-12-16)
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