Women's Health Weekly
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Atherosclerosis
LCAT induces estradiol esterification in HDL, boosting antioxidant potential
December 23rd, 2004
University of Helsinki cardiologists have shown that lecithin/cholesterol acyltransferase is involved in estradiol esterification and antioxidant protection of high density lipoprotein. "Endogenous estrogens protect against atherosclerosis, but the exact mechanisms remain unclear. One possibility is inhibition of lipoprotein oxidation," wrote A. Hockerstedt and colleagues. "To act as antioxidants, estrogens reportedly need to be converted to lipophilic estrogen fatty acyl esters in a reaction catalyzed by lecithin/cholesterol acyltransferase (LCAT). "To demonstrate directly that estradiol (E2) esters formed by LCAT and...
Source: Women's Health Weekly (2004-12-23)
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