Women's Health Weekly
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Cancer Genetics
Recurrent chromosome breakpoint at NRG1/Neuregulin 1/Heregulin gene studied
December 23rd, 2004
According to a report from England, "Most studies of genomic rearrangements in common cancers have focused on regional gains and losses, but some rearrangements may break within specific genes. "We previously reported that five breast cancer cell lines have chromosome translocations that break in the NRG1 gene and that could cause abnormal NRG1 expression. NRG1 encodes the Neuregulins I (formerly the Heregulins), ligands for members of the ErbB/epidermal growth factor-receptor family, which includes ErbB2/HER2," said H.E. Huang and colleagues, University of Cambridge. Huang's team have screened for chromosomal "breaks at NRG1 in paraffin sections of...
Source: Women's Health Weekly (2004-12-23)
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