Women's Health Weekly
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Endocrinology
Epidemiologic study looks at gene polymorphisms affecting hormone levels
December 23rd, 2004
According to recent research published in the American Journal of Epidemiology, "The cytochrome P-450c17alpha (CYP17) gene, located on chromosome 10q24.3, encodes the enzyme cytochrome P-450c17alpha, which functions at key branch points in steroid hormone biosynthesis. "Three polymorphisms have been described, but only the single base-pair change in the 5'-untranslated region (5'-UTR) has been investigated to any great extent," said L. Sharp and colleagues, National Cancer Registry Ireland. "In single studies, the variant was associated with reduced messenger RNA level in ovarian cells but not with messenger RNA level in breast tissue," the...
Source: Women's Health Weekly (2004-12-23)
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