Women's Health Weekly
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Fetal Development
Non-viral gene transfer tracks gene expression in murine embryos
December 23rd, 2004
Non-viral gene transfer tracks gene expression in murine embryos. "The surface epithelium of mid-gestational murine embryos is thought to be an attractive target for gene therapy in vivo, due to its visibility and accessibility from the external surface of the maternal uterus. Almost all studies of in utero gene transfer have adopted viral vectors for infection of fetal epithelium, and depended on intraamniotic introduction and simple incubation of vectors, leading to only infection of the surface layer (periderm) of fetal skin," according to researchers in Japan. "Here we report a simple and convenient method of gene transfer of plasmid DNA into the...
Source: Women's Health Weekly (2004-12-23)
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