Women's Health Weekly
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Brucella Abortus
B. abortus Znu locus required for survival and virulence in mice
December 30th, 2004
According to published research from Japan, the zinc uptake system (ZnuA locus) of Brucella abortus is essential for intracellular survival and virulence in mice. "Brucella spp. are facultative intracellular pathogens that have the ability to survive and multiply in professional and nonprofessional phagocytes, and cause abortion in domestic animals and undulant fever in humans. The mechanism and factors of virulence are not fully understood," wrote S. Kim and colleagues, Obihiro University of Agriculture & Veterinary Medicine. "[A] high-affinity zinc uptake system protein mutant (znuA mutant) showed reduced growth in zinc chelated...
Source: Women's Health Weekly (2004-12-30)
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