Women's Health Weekly
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Cancer Genetics
Mutation panel described for screening BRCA1/2 mutations in French Canadians
December 30th, 2004
Researchers with the Montreal General Hospital reported in 1998 "that a significant proportion of breast and/or ovarian cancer families of French Canadian descent harbor specific germline mutations in BRCA1 or BRCA2 attributed to common founders." Now, in a paper in the International Journal of Cancer, the team has determined "the frequency of previously described mutations (n=7) and 13 mutations identified in French Canadian families since 1998, in a new group of families (n=88)." K.K. Oros and colleagues reported, "Four of the previously described mutations, 4446C > T, 2953delGTAinsC, 8765delAG, and 6085C > T, account for 72% and 69%...
Source: Women's Health Weekly (2004-12-30)
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