Women's Health Weekly
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Cancer Genetics
Penetrance functions for software predicts cancer risk among BRCA1/2 carriers
December 30th, 2004
According to a study from Italy, "Accurate estimates of breast and ovarian cancer penetrance in BRCA1/2 mutation carriers are crucial in genetic counseling. "Estimation is difficult because of the low frequency of mutated alleles and the often-uncertain mechanisms of family ascertainment." F. Marroni at the University of Pisa and colleagues "estimated the penetrances of breast and ovarian cancers in carriers of BRCA1/2 mutations by maximizing the retrospective likelihood of the genetic model, given the observed test results, in 568 Italian families screened for germline mutations." "The software BRCAPRO was used as a probability...
Source: Women's Health Weekly (2004-12-30)
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