Women's Health Weekly
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Cardiology
Pressure-overload on the late-fetal heart induces limited proliferative growth
December 30th, 2004
Increased cardiac workload by closure of the ductus arteriosus leads to hypertrophy and apoptosis rather than to hyperplasia in the late fetal period. According to scientists writing in the journal Naunyn - Schmiedebergs Archives of Pharmacology, "It is generally thought that adult mammalian cardiomyocytes compensate for an increased workload by hypertrophy, whereas fetal myocardium grows by cellular proliferation. We analyzed the response of late-fetal rat hearts upon an increased workload imposed by premature constriction of the ductus arteriosus with indomethacin." M.J. van den Hoff and colleagues of the University of Amsterdam reported,...
Source: Women's Health Weekly (2004-12-30)
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