Women's Health Weekly
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Cervical Cancer
Proteomic approach used to study cisplatin resistance in human cell lines
December 30th, 2004
According to published research from Italy, "Since drug resistance is a complex and multifactorial event involving activation/repression of multiple biochemical pathways, we used a proteomic approach to study cisplatin resistance and drug response in human tumor cell lines." A. Castagna and colleagues, University of Verona, used "the cervix squamous cell carcinoma cell line A431 and its cisplatin-resistant subline, A431/Pt ... as a model system. The experimental set-up involved not just a two-way comparison of the control vs. the drug-resistant cell line, but also an acute cisplatin treatment of both cell lines, leading to a four-way comparison, as follows: 1) A431 vs....
Source: Women's Health Weekly (2004-12-30)
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