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Atherosclerosis

Rat study suggests low-dose estrogen protects against clogged arteries

Published in Women's Health Weekly, January 6th, 2005

Data from experiments in rat carotid arteries suggest low-dose estrogen protects against atherosclerosis.

"The current regimens of hormone replacement therapy for postmenopausal women, estrogen combined with progestogen, have failed to show beneficial effects for the prevention of atherosclerotic disease. Although the relatively higher dose of estrogen contained in those regimens exerted adverse effects, there are few data examining a lower dose of estrogen in an atherosclerosis model," wrote T. Watanabe, University of Tokyo, and colleagues.

Thus, they "investigated experimentally whether lower doses of estrogen could inhibit neointimal formation...

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