Women's Health Weekly
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Breast Cancer
Breast cancer resistance to IR-induced apoptosis caused by independent events
January 6th, 2005
Breast cancer cell resistance to ionizing radiation-induced apoptosis is caused by independent events. "We have shown previously that ionizing radiation (IR) induces a persistent G2 -M arrest but not cell death in MCF-7 breast carcinoma cells that harbor functional p53 but lack caspase-3. "In the present study, we investigated the mechanisms of apoptosis resistance and the roles of p53, caspase-3, and cell cycle arrest in IR-induced apoptosis," scientists writing in the journal Cancer Research report. "The methylxanthine caffeine and the staurosporine analog UCN-01, which can inhibit ATM and Chk kinases,...
Source: Women's Health Weekly (2005-01-06)
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