Women's Health Weekly
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Breast Cancer
Deregulation of BTG2 expression may be important in mammary tumor development
January 6th, 2005
Deregulation of BTG2 gene expression may be important in mammary tumor development, suggest oncologists at the Massachusetts General Hospital, Boston. "BTG2, a p53-inducible antiproliferative gene, is stimulated in breast cancer cells by activation of nuclear factor kappa B (NF-kappaB). In rat mammary glands, BTG2 is expressed in epithelial cells and levels decreased during pregnancy and lactation, but recovered during involution," according to H. Kawakubo and colleagues. "Estrogen and progestin suppress BTG2 expression, suggesting that these steroids, which stimulate proliferation and lobuloalveolar development of mammary epithelial cells, may...
Source: Women's Health Weekly (2005-01-06)
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