Women's Health Weekly
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Breast Cancer
Novel quinazoline has multiple mechanisms of action in breast cancer cells
January 6th, 2005
A novel quinazoline has multiple mechanisms of action in breast cancer cells. "The mechanism of action of ZR2002, a chimeric amino quinazoline designed to possess mixed EGFR tyrosine kinase (TK) inhibitory and DNA targeting properties, was compared to those of ZR01, a reversible inhibitor of the same class and PD168393, a known irreversible inhibitor of EGFR. "ZR2002 exhibited 4-fold stronger EGFR TK inhibitory activity than its structural homologue ZR01 but was approximately 3-fold less active than the 6-acrylamidoquinazoline PD168393. It preferentially blocked EGF and TGFalpha-induced cell growth over PDGF and serum," scientists in Canada...
Source: Women's Health Weekly (2005-01-06)
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