Women's Health Weekly
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Breast Cancer
Syndecan-1 ectodomain regulates matrix-dependent signaling in breast cancer cell
January 6th, 2005
Syndecan-1 ectodomain regulates matrix-dependent signaling in breast cancer cells. "Syndecan-1 was overexpressed in T47D, MCF-7, or Hs578t human breast carcinoma cell lines, mimicking overexpression observed in carcinomas in vivo. Overexpression of syndecan-1, or its ectodomain alone fused to a glycosylphosphatidylinositol anchor (GPI-mS1ED), promotes cell rounding in 2D culture. "Deletions within the syndecan-1 ectodomain (S1ED) implicate an active site within the core protein between the glycosaminoglycan attachment region and the transmembrane domain," scientists in the United States report. "Polyclonal antibodies directed...
Source: Women's Health Weekly (2005-01-06)
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