Women's Health Weekly
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Down Syndrome
Antioxidant capacity in Down syndrome, greater astrocyte capacity revealed
January 6th, 2005
According to a study from Spain, Down syndrome astrocytes have greater antioxidant capacity than euploid astrocytes. "Down's syndrome (trisomy 21) brain tissue is considered to be susceptible to oxidative injury, mainly because its increased Cu/Zn-superoxide dismutase (SOD1) activity is not followed by an adaptive rise in hydrogen peroxide metabolizing enzymes. "In vitro," wrote J. Sebastia and colleagues, "trisomic neurons suffer oxidative stress and degenerate." "We studied the response of trisomy 21 neuron and astrocyte cultures to hydrogen peroxide injury and found that they were, respectively, more and less vulnerable than...
Source: Women's Health Weekly (2005-01-06)
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