Women's Health Weekly
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Antiphospholipid Syndrome
Heparin blocks activation of complement-induced by aPL
January 6th, 2005
According to a study from the United States, "The antiphospholipid syndrome (APS) is defined by thrombosis and recurrent pregnancy loss in the presence of antiphospholipid (aPL) antibodies and is generally treated with anticoagulation therapy. "Because complement activation is essential and causative in aPL antibody-induced fetal injury, we hypothesized that heparin protects pregnant APS patients from complications through inhibition of complement," said G. Girardi and colleagues, Hospital for Special Surgery, New York City. They observed that "treatment with heparin (unfractionated or low molecular weight) prevented complement activation in vivo and...
Source: Women's Health Weekly (2005-01-06)
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