Women's Health Weekly
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Breast Cancer
Adenoviral vectors that express EphrinA1 staunch breast tumor growth
January 13th, 2005
Adenoviral vectors that express EphrinA1 staunch breast tumor growth. According to a study from the United States, "the EphA2 receptor tyrosine kinase is frequently overexpressed in invasive breast cancer cells. Moreover, these malignant cells have unstable cell-cell contacts, which preclude EphA2 from interacting with its ligand, EphrinA1, which is anchored to the membrane of adjacent cells. This defect is important because ligand binding causes EphA2 to transmit signals that negatively regulate tumor cell growth and survival, whereas the absence of ligand binding favors these same behaviors." "In our present study, human adenoviral type 5 (HAd)...
Source: Women's Health Weekly (2005-01-13)
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