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Ovarian Cancer

EMAST is a distinct form of microsatellite instability in ovarian cancer

Published in Women's Health Weekly, January 13th, 2005

Elevated microsatellite alterations at selected tetranucleotides, or EMAST, appears to be a distinct form of microsatellite instability in ovarian cancer, pathologists report.

"Microsatellite instability at mono- and dinucleotide repeats is the hallmark of the hereditary non-polyposis cancer syndrome (HNPCC) and is related to deficient DNA mismatch repair. In contrast, [EMAST], a distinct form of microsatellite instability at selective tetranucleotide repeats, was described in several non-HNPCC cancer types. EMAST is probably unrelated to mismatch repair defects," said G. Singer and colleagues, University of Basel, Switzerland.

This team...

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