Published in Women's Health Weekly, January 13th, 2005
"Ovarian carcinoma cells express both the IL-12Rbeta1 and the IL-12Rbeta2 subunits. IL-12R crosslinking resulted in phosphorylation of Tyk2, p44 (ERK1) and Akt kinases and activation of STATs 2, 3, 4, and 5," the researchers said.
"IL-12 induced substantial upregulation of Fas ligand (FasL) surface expression in ovarian...
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