Women's Health Weekly
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Breast Cancer
Autocrine neuregulin signaling loop identified in breast tumor cells
January 13th, 2005
A novel autocrine neuregulin (NRG) signaling loop plays a key role in the proliferation of breast tumor cells. NRG "is a heparin-binding factor that activates members of the epidermal growth factor family of tyrosine kinase receptors including erbB2 that is overexpressed in more aggressive types of breast cancer," researchers in Michigan explained. "The exact role that NRG plays in breast cancer is complicated by the fact that NRG has been shown to have both proliferative and antiproliferative effects, depending on the breast cancer cell line used." "Using an isogenic series of breast epithelial cell lines (MCF10A) ranging from benign to malignant,"...
Source: Women's Health Weekly (2005-01-13)
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