Women's Health Weekly
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Breast Cancer
Novel enzyme protects breast tumor cells from oxidative stress
January 13th, 2005
A novel enzyme plays a key role in protecting breast tumor cells from oxidative stress. In a recent study from the United States, a "dramatic reduction in the expression of a novel phospholipid hydroperoxide glutathione peroxidase (PHGPx), which incorporates cysteine instead of selenocysteine in the conserved catalytic motif was observed in a microarray analysis using cDNAs amplified from mRNA of Brca1-null mouse embryonic fibroblasts." "This non-selenocysteine PHGPx named NPGPx is a cytoplasmic protein with molecular mass of approximately 22 kDa and has little detectable glutathione peroxidase activity in vitro," reported A. Utomo and coauthors at...
Source: Women's Health Weekly (2005-01-13)
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