Women's Health Weekly
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Breast Cancer
CD8+ T cells from breast cancer patients recognize mammaglobin epitopes
January 20th, 2005
CD8+ cytotoxic T lymphocytes from breast cancer patients recognize HLA-A2-restricted mammaglobin-A-derived epitopes. "A breast cancer-associated antigen, mammaglobin-A, is specifically expressed in 80% of primary breast tumors. The definition of immune responses against this highly expressed breast cancer-specific antigen should be of great value in the development of new therapeutic strategies for breast cancer. Thus, the purpose of this study was to identify HLA-A2-restricted mammaglobin-A- derived epitopes recognized by CD8+ cytotoxic T lymphocytes (CTL). We identified seven mammaglobin-A-derived candidate epitopes that bind the HLA-A2 molecule (Mam-A2.1-7) by means...
Source: Women's Health Weekly (2005-01-20)
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