Women's Health Weekly
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Breast Cancer
Matrix metalloproteinases are prognostic in patients with breast cancer
January 20th, 2005
Matrix metalloproteinases have prognostic value in patients with lymph node-negative breast carcinoma. "Twenty-five to 30% of patients with node-negative breast cancer are expected to relapse following surgery, therefore great efforts have been made to identify new prognostic markers that could be useful in defining patients for additional therapy. The expression of MMP-2 and MMP-9 has been associated with high potential of metastasis in several human carcinomas including breast cancer. In the present study we examined the prognostic value of immunoreactive MMP-2/MMP-9 protein in 270 consecutive lymph node negative cases who received radical mastectomy or modified...
Source: Women's Health Weekly (2005-01-20)
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