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Complementary and Alternative Medicine

Further study needed on safety of St. John's wort during pregnancy, lactation

Published in Women's Health Weekly, January 20th, 2005

Researchers say more study is needed to determine the safety of using St. John's wort (Hypericum perforatum) during pregnancy and breastfeeding.

"The popularity of St. John's wort ... for the treatment of depression is increasing and, in recent years, concerns about its use during pregnancy and breastfeeding have emerged," noted B. Gregoretti and colleagues, University of Trieste, Italy.

They conducted a study in Wistar rats "of a treatment with hypericum administered prenatally and during breastfeeding (from 2 weeks before mating to 21 days after delivery). Two doses of the extract were chosen, 100 mg/kg per day, which, based on surface area,...

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