Women's Health Weekly
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Carcinogenesis
Apoptosis-associated genes regulated in response to DES identified in mice
January 20th, 2005
Researchers in Malaysia have identified in a mouse model apoptosis-associated genes regulated in response to diethylstilbestrol (DES). "Studies with clastogenic carcinogen diethylstilbestrol resulted in a broad of spectrum of toxic and carcinogenic effects in humans and rodents, but the cellular and molecular mechanism(s) by which it induces cancer is not clear. To identify putative genetic targets for p53 in vivo, we applied the cDNA macroarray gene expression profiles associated with apoptosis by comparing p53+/- knockout mice and wild-type mice on the kidney and uterus of female mice," reported M.N. Salleh and colleagues, University of Putra Malaysia,...
Source: Women's Health Weekly (2005-01-20)
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