Women's Health Weekly
Welcome to NewsRx!
Learn more about a six-week, no-risk free trial of Women's Health Weekly
We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.
Atherosclerosis
COX-2-derived prostacyclin confers atheroprotection on female mice
January 27th, 2005
Cyclooxygenase 2 (COX-2)-derived prostacyclin conferred atheroprotection on female mice in experiments by University of Pennsylvania scientists. K.M. Egan and colleagues wrote, "Female gender affords relative protection from cardiovascular disease until the menopause. We report that estrogen acts on estrogen receptor subtype alpha to upregulate the production of atheroprotective prostacyclin, PGI(2), by activation of COX-2." This mechanism restrained both oxidant stress and platelet activation that contribute to atherogenesis in female mice. Deletion of the PGI(2) receptor removed the atheroprotective effect of estrogen in ovariectomized female...
Source: Women's Health Weekly (2005-01-27)
|
