Women's Health Weekly
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Breast Cancer
Drugs induce superinvasive phenotype in breast cancer cells
January 27th, 2005
A new superinvasive in vitro phenotype was induced by selection of human breast carcinoma cells with the chemotherapeutic drugs paclitaxel and doxorubicin. "Doxorubicin- and paclitaxel-selected variants of an in vitro invasive clonal population of the human breast cancer cell line, MDA-MB-435S, were established by pulse selection, and exhibited a novel 'superinvasive' phenotype. This phenotype is characterized by an ability to relocate to another surface following invasion through matrigel and membrane pores, by decreased adhesion to extracellular matrix proteins and by increased motility. This may represent an in vitro model of a step in the metastatic process...
Source: Women's Health Weekly (2005-01-27)
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