Women's Health Weekly
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Cancer Genetics
Loss of BRCA1 function associated with sensitivity to DNA-damaging chemotherapy
January 27th, 2005
Loss of BRCA1 function is associated with sensitivity to DNA-damaging chemotherapy, report oncologists. "Germline mutations of the BRCA1 gene account for approximately 5% of breast and ovarian cancer cases, and lower than normal BRCA1 expression or function may be an important contributing factor in sporadic cancers," wrote R.D. Kennedy and colleagues, Queen's University Belfast, Belfast City Hospital. "The major role of BRCA1 is to respond to DNA damage by participating in cellular pathways for DNA repair, mRNA transcription, cell cycle regulation, and protein ubiquitination. Because most chemotherapeutic agents function by directly or indirectly...
Source: Women's Health Weekly (2005-01-27)
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