Women's Health Weekly
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Candidiasis
CaMIT1 inactivation reduces Candida albicans virulence
January 27th, 2005
Inactivation of CaMIT1 inhibits Candida albicans phospholipomannan beta-mannosylation, reduces virulence, and alters cell wall protein beta-mannosylation. According to a study from France, "Studies on Candida albicans phospholipomannan have suggested a novel biosynthetic pathway for yeast glycosphingolipids. This pathway is thought to diverge from the usual pathway at the mannose-inositol-phosphoceramide (MIPC) step. To confirm this hypothesis, a C. albicans gene homologue for the Saccharomyces cerevisiae SUR1 gene was identified and named MIT1 as it coded for GDP-mannose: inositol-phospho-ceramide mannose transferase. Two copies of this gene...
Source: Women's Health Weekly (2005-01-27)
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