Women's Health Weekly
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Cell Differentiation
Claudin localization is regulated in developing by fetal alveolar epithelia
January 27th, 2005
Researchers from the United States have reported on the developmental regulation of claudin localization in fetal alveolar epithelial cells. "Tight junction proteins in the claudin family regulate epithelial barrier function. We examined claudin expression by human fetal lung (HFL) alveolar epithelial cells cultured in medium containing dexamethasone, 8-bromo-cAMP, and isobutylmethylxanthanine (DCI), which promotes alveolar epithelial cell differentiation to a type II phenotype. "At the protein level, HFL cells expressed claudin-1, claudin-3, claudin-4, claudin-5, claudin-7, and claudin-18, where levels of expression varied with culture conditions,"...
Source: Women's Health Weekly (2005-01-27)
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